Season 5 of Chicago P.D. originally aired on NBC from September 27, 2017 to May 9, 2018. This season consisted of 22 episodes.
- Jason Beghe as Sergeant Hank Voight
- Jon Seda as Detective Antonio Dawson
- Jesse Lee Soffer as Detective Jay Halstead
- Tracy Spiridakos as Detective Hailey Upton
- Patrick John Flueger as Officer Adam Ruzek
- Marina Squerciati as Officer Kim Burgess
- LaRoyce Hawkins as Officer Kevin Atwater
- Elias Koteas as Detective Alvin Olinsky
- Amy Morton as Desk Sergeant Trudy Platt
- Chicago Med
- Chicago Fire
- The Thing About Heroes
- Care Under Fire
- Rabbit Hole
- Chasing Monsters
- Breaking Point
- Chicago P.D. - Season 5 Episode 16 - Profiles
- Chicago Fire - Season 6 Episode 13 - Hiding Not Seeking
On May 25, 2017, it was announced that Sophia Bush has departed the series, while Jon Seda is set to return after the cancellation of Chicago Justice. After recurring last season, as Detective Hailey Upton, Tracy Spiridakos has been promoted to a series regular for this season.
Mykelti Williamson will reprise his role of Lieutenant Denny Woods in a recurring role, and Wendell Pierce will join the cast as Alderman Ray Price, in a recurring role.